Funded by the EU 6th Framework Programme – Project EC LSH-037315
Epicure has made the headlines in Italy. It was reported by the Italian national news agency ANSA who described how neurotrophic factors have been found which could prevent spontaneous seizures in an epilepsy model. Thua research was carried out by EPICUREs Michele Simonatos team at the University of Ferrara and published in PNAS in April 2009.
The novel aspect of this research is that a genetically modified virus is used to administer the proteins to the brain. A study in rats suggests that localized hippocampal delivery of FGF-2 and BDNF may be useful for decreasing seizure frequency. In a rat model of epilepsy, hippocampal delivery of a vector contain